This protein binding is reversible and independent of total drug concentrations. Following a single oral dose of 20 mg vardenafil in healthy volunteers, a mean of 0.00018% of the administered dose was obtained in semen 1.5 hours after dosing. Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms.
Vardenafil dosing information
It should not be used with the recreational drugs, amyl nitrate and butyl nitrate, also known as poppers. Other drugs that may interact include, but are not limited to: drugs for prostate problems, blood pressure, or heart rhythm disorders Grapefruit juice contains a chemical that makes adverse effects more likely, so it should not be consumed while using vardenafil. Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. Patients should tell their doctor about all their medical conditions and any other medications or supplements they use before taking vardenafil.
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This is especially important if they have: a deformity in the shape of the penis, such as Peyronie’s disease a heart condition, such as arrhythmia, heart failure, or angina a family history of a rare heart condition known as long QT syndrome hemophilia or some kind of bleeding problem hypotension (low blood pressure) or hypertension (high blood pressure) multiple myeloma, leukemia, sickle cell anemia, or some other kind of blood cell problem non-arteritic anterior ischemic optic neuropathy (NAION) damage to the retina of the eye retinitis pigmentosis, a rare genetic eye disease They should also tell the doctor if they have ever experienced priapism, a seizure, or if they have recently had a stroke or a heart attack. Levitra is available to purchase online, but users should consider the above points and check with their health provider first. If any adverse effects occur, users are encouraged to LEVITRA- vardenafil hydrochloride tablet, film coated APHENA PHARMA SOLUTIONS - TENNESSEE, INC. LEVITRA® is an oral therapy for the treatment of erectile dysfunction. Vardenafil HCl is designated chemically as piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f ][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride and has the following structural formula: Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water.
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LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on one side and “2.5”, “5”, “10”, and “20” on the other side corresponding to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively. The most abundant PDE in the flibanserin human corpus cavernosum is the cGMP-specific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP. The pharmacokinetics of vardenafil are approximately dose proportional over the recommended dose range. Vardenafil is eliminated predominantly by hepatic metabolism, mainly by CYP3A4 and to a minor extent, CYP2C isoforms. Concomitant use with potent CYP3A4 inhibitors such as ritonavir, indinavir, ketoconazole, as well as moderate CYP3A inhibitors such as erythromycin results in significant increases of plasma levels of vardenafil (see PRECAUTIONS, WARNINGS and DOSAGE AND ADMINISTRATION). Therefore, M1 accounts for approximately 7% of total pharmacologic activity. The total body clearance of vardenafil is 56 L/h, and the terminal half-life of vardenafil and its primary metabolite (M1) is approximately 4-5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Soft Tabs | 100mg | 60 + 6 Pills | 152.94€ 145.66€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Cialis Generic | 60mg | 90 + 6 Pills | 196.67€ 187.30€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Cialis Generic | 5mg | 30 + 4 Pills | 53.56€ 51.01€ | |
| Levitra Generic | 60mg | 360 + 10 Pills | 906.69€ 863.51€ | |
| Cialis Generic | 2.5mg | 270 + 10 Pills | 199.64€ 190.13€ | |
| Cialis Generic | 60mg | 20 Pills | 65.61€ 62.49€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Levitra Generic | 60mg | 180 + 10 Pills | 501.43€ 477.55€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ |
Pediatrics: Vardenafil trials were not conducted in the pediatric population.
5.14 Sexually Transmitted Disease
Vardenafil is available in tablets of 2.5 milligrams (mg), 5 mg, 10 mg, and 20 mg. The first dose is normally 10 mg. A 10-mg dose of vardenafil is approximately equivalent to 50 mg of sildenafil, or Viagra. This is because the chemical composition of vardenafil is different from that of sildenafil. Vardenafil is taken 25 to 60 minutes before sex.
Mechanism of Action
The effect lasts for up to 5 hours. A maximum of one tablet can be used every 24 hours. Orodispersible tablets must be left to dissolve on the tongue before swallowing. They should not be taken with any kind of drink. The drug will not work unless the man is sexually aroused, so foreplay will normally be necessary.
Usual Adult Dose for:
Vardenafil can be taken with or without food, but drinking alcohol is not advised, as it reduces the chance of getting an erection. Alcohol can also increase the risk of adverse effects. As with all medications, adverse effects and interactions can occur when using vardenafil. One in 10 men will experience headache. In most cases, these disappear within a few hours. Geriatrics: In a healthy volunteer study of elderly males (≥65 years) and younger males (18–45 years), mean Cmax and AUC were 34% and 52% higher, respectively, in the elderly males (see PRECAUTIONS, Geriatric Use and DOSAGE AND ADMINISTRATION).
| Advice Point | Explanation |
|---|---|
| Take on an empty stomach | Food, especially high-fat, may delay absorption |
| Do not combine with nitrates | Can cause severe hypotension |
| Avoid alcohol consumption | Can impair effectiveness and cause side effects |
| Follow prescribed dosage | To minimize side effects and interactions |
Consequently, a lower starting dose of LEVITRA (5 mg) in patients ≥65 years of age should be considered.
- Vardenafil 10 mg is one of several ED treatment options.
- It is generally well-tolerated when used properly.
- Take care to follow your healthcare provider’s instructions.
- Possible interactions with antihypertensive drugs exist.
- Do not drive or operate machinery if feeling dizzy.
- Keep a record of any side effects experienced.
- The medication is not a cure for erectile dysfunction.
- Combining vardenafil with other ED drugs is dangerous.
- Take the tablet with a full glass of water.
- Consult your doctor for dose adjustments if needed.
Renal Insufficiency: In volunteers with mild renal impairment (CLcr = 50-80 ml/min), the pharmacokinetics of vardenafil were similar to those observed in a control group with normal renal function.
| Patient Type | Recommended Dose | Notes |
|---|---|---|
| Adult Men with ED | 10 mg | 1 hour before activity |
| Elderly Patients | 5-10 mg | Adjust based on tolerability |
| Patients with Liver Impairment | 5 mg | Lower dose recommended |
| Use with CYP3A4 inhibitors | 5 mg | To reduce adverse risk |
In the moderate (CLcr = 30-50 ml/min) or severe (CLcr<30 ml/min) renal impairment groups, the AUC of vardenafil was 20–30% higher compared to that observed in a control group with normal renal function (CLcr>80 ml/min).
- Vardenafil 10 mg is a selective phosphodiesterase type 5 inhibitor.
- It can improve the ability to achieve an erection.
- Maintain open communication with your healthcare provider.
- Use with caution in elderly patients.
- Report any unusual side effects promptly.
- The medication should not be used recreationally.
- Not recommended for use with certain antihypertensives.
- Effectiveness depends on correct timing and dosage.
- Avoid taking if you have severe liver disease.
- Always read the patient information leaflet.
Vardenafil pharmacokinetics have not been evaluated in patients requiring renal dialysis (see PRECAUTIONS, Renal Insufficiency, and DOSAGE AND ADMINISTRATION).
- The onset of vardenafil 10 mg is typically 30-60 minutes.
- It can last up to 4-5 hours in some users.
- Vardenafil is contraindicated with certain heart medications.
- Use caution if you have a history of hypotension.
- The tablet may cause mild gastrointestinal upset.
- Do not consume large amounts of alcohol when taking vardenafil.
- Inform your doctor if you experience sudden hearing loss.
- Use only as directed by your healthcare provider.
- Discontinue if you experience persistent erection issues.
- The medication does not increase sexual desire.
Hepatic Insufficiency: In volunteers with mild hepatic impairment (Child-Pugh A), the Cmax and AUC following a 10 mg vardenafil dose were increased by 22% and 17%, respectively, compared to healthy control subjects. In volunteers with moderate hepatic impairment (Child-Pugh B), the Cmax and AUC following a 10 mg vardenafil dose were increased by 130% and 160%, respectively, compared to healthy control subjects.
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Mean vardenafil plasma concentrations measured after the administration of a single oral dose of 20 mg to healthy male volunteers are depicted in Figure 1. Figure 1: Plasma Vardenafil Concentration (Mean ± SD) Curve for a Single 20 mg LEVITRA Dose Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%. Maximum observed plasma concentrations after a single 20 mg dose in healthy volunteers are usually reached between 30 minutes and 2 hours (median 60 minutes) after oral dosing in the fasted state. Two food-effect studies were conducted which showed that high-fat meals caused a reduction in Cmax by 18%-50%. The mean steady-state volume of distribution (Vss) for vardenafil is 208 L, indicating extensive tissue distribution. Consequently, a starting dose of 5 mg is recommended for patients with moderate hepatic impairment, and the maximum dose should not exceed 10 mg (see PRECAUTIONS and DOSAGE AND ADMINISTRATION). In a clinical pharmacology study of patients with erectile dysfunction, single doses of vardenafil 20 mg caused a mean maximum decrease in supine blood pressure of 7 mmHg systolic and 8 mmHg diastolic (compared to placebo), accompanied by a mean maximum increase of heart rate of 4 beats per minute. Vardenafil may add to the blood pressure lowering effects of antihypertensive agents (see PRECAUTIONS, Drug Interactions). A study was conducted in which the blood pressure and heart rate response to 0.4 mg nitroglycerin (NTG) sublingually was evaluated in 18 healthy subjects following pretreatment with LEVITRA 20 mg at various times before NTG administration. LEVITRA 20 mg caused an additional time-related reduction in blood pressure and increase in heart rate in association with NTG administration.
5.12 Phenylketonurics
ringing in the ears, or sudden hearing loss swelling in the ankles, hands, or feet The patient should stop using vardenafil if these occur. This can lead to hives, difficulty breathing, and swelling of the face, tongue, and throat. If these symptoms appear, it should be treated as a medical emergency. Very rare side effects may include priapism, when an erection lasts longer than 4 hours. If an erection lasts too long, the individual should seek medical attention.
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Visual disturbances can happen when blood pressure drops in the eye. The individual may see a blue tinge to objects, and they may have difficulty distinguishing between the colors green and blue. Very rarely, there may be a sudden deterioration in vision in one or both eyes. This can indicate a heart condition, an existing eye problem, high cholesterol, diabetes, or hypertension. If any sudden loss of vision occurs, the individual should stop taking the medication and seek medical help immediately.
Does vardenafil interact with other medicines (drug interactions)?
Vision problems are most likely in patients with other conditions, such as heart or coronary blue tablets artery disease, diabetes, and high cholesterol. Vision problems are more likely to happen if the person smokes, or if they are aged over 50 years. Using vardenafil with some other drugs can lead to serious adverse effects. a potentially dangerous drop in blood pressure, or hypotension There is also a risk of stroke and heart attack. A man should not use vardenafil if he is taking nitrate drugs, such as riociguat (Adempas), or other nitrate drugs for chest pain or heart problems. The blood pressure effects were observed when LEVITRA 20 mg was dosed 1 or 4 hours before NTG and the heart rate effects were observed when 20 mg was dosed 1, 4, or 8 hours before NTG.
| Measure | Result | Timeframe | Notes |
|---|---|---|---|
| Erection Success Rate | 70-80% in clinical trials | After 1 Dose | High efficacy reported |
| Patient Satisfaction | 75% reported improvement | After 4 weeks | Based on surveys |
| Onset Time | 30-60 minutes | Post-dose | Rapid onset for most patients |
| Duration of Effect | 4-5 hours | After intake | Provides window for activity |
Additional blood pressure and heart rate changes were not detected when LEVITRA 20 mg was dosed 24 hours before NTG. Figure 2: Placebo-subtracted point estimates (with 90% CI) of mean maximal blood pressure and heart rate effects of pre-dosing with LEVITRA 20 mg at 24, 8, 4, and 1 hour before 0.4 mg NTG sublingually.