After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at By reporting side effects, you can help provide more information on the safety of this medicine. Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines. This medicine is only available with a doctor's prescription. This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes. Do not take this medicine if you are allergic to any of these ingredients.

Contra Indications

PRILIGY should be taken as needed, when sexual activity is anticipated. As PRILIGY is only taken when needed, it is not a problem if you forget to take it. Tell your doctor or pharmacist if you have taken more PRILIGY tablets than you should. Symptoms of overdose in PRILIGY are drowsiness, nausea, vomiting, rapid heartbeat, tremor, agitation and dizziness. If you think that you have taken too much PRILIGY, you may need urgent medical attention.

Priligy Dapoxetine 30 mg: Mechanism of Action or How does it work against premature ejaculation (PE)?

phone the Poisons Information Centre (by calling 13 11 26), or go to the Emergency Department at your nearest hospital. You should do this even if there are no signs of discomfort or poisoning. WARNING: PRILIGY can make you faint or make you feel dizzy or light-headed. To help lower the chance of this happening: Take PRILIGY with at least one full glass of water. Do not take PRILIGY if you are dehydrated (you do not have enough water in your body). PRILIGY 30 mg film-coated tablets are light grey, round and marked "30" inside a triangle on one side (AUST R 147946). PRILIGY is supplied in blister packs containing 3 or 6 tablets.

Aspect	Description	Approved Uses
Active Ingredient	Dapoxetine	Premature Ejaculation
Drug Class	Selective Serotonin Reuptake Inhibitor (SSRI)	Sexual Dysfunction Treatment
Manufacturer	Johnson & Johnson	Approved Countries
Typical Dosage	30 mg or 60 mg	Usage Guidelines

This leaflet was prepared in March 2024.

Priligy helps improve control over ejaculation.
It is generally well-tolerated with few side effects.
Patients should avoid driving after use.
Overdose can cause serious health issues.
Use only as directed by your healthcare provider.
Priligy is not recommended for women.
It's effective for rapid ejaculation lasting less than 1 minute.
The medication can be part of a broader treatment plan.
Regular medical check-ups are advised during use.

Dapoxetine, sold under the brand name Priligy among others, is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation (PE) in men ages 18 to 64 years old.

Dapoxetine acts quickly to increase control.
It is not intended for daily continuous use.
Side effects may decrease over time.
Patients should report severe adverse reactions.
Avoid using in combination with MAO inhibitors.
The medication is classified as a prescription drug.
It is not suitable for palliative or hospice care.
Proper hydration can help mitigate some side effects.
Always inform your healthcare provider of all medications.

[3][4][5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay.

Side Effect	Incidence Rate	Severity	Management Tips
Nausea	10-15%	Mild	Take with food
Dizziness	5-8%	Mild to Moderate	Avoid alcohol, rise slowly
Headache	10-12%	Mild	Over-the-counter pain relief
Diarrhea	3-5%	Mild	Hydration, monitor symptoms

[6] As a member of the SSRI family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast-acting property makes it suitable for the treatment of PE, but not as an antidepressant. Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the US Food and Drug Administration (FDA) for the treatment of PE in 2004. [8] Dapoxetine is sold in several European and Asian countries, and in Mexico.

Product	Dosage	Quantity + Bonus	Price
Priligy Generic Dapoxetine	60mg	10 Pills	47.63€ 45.36€
Priligy Generic Dapoxetine	60mg	180 + 10 Pills	494.76€ 471.20€
Viagra Generic	25mg	10 Pills	25.19€ 23.99€
Priligy Generic Dapoxetine	60mg	20 + 4 Pills	77.31€ 73.63€
Priligy Generic Dapoxetine	60mg	60 + 8 Pills	183.06€ 174.34€
Priligy Generic Dapoxetine	60mg	90 + 10 Pills	265.64€ 252.99€
Kamagra	100mg	180 + 6 Pills	436.79€ 415.99€
Levitra Generic	40mg	30 + 2 Pills	93.58€ 89.12€
Priligy Generic Dapoxetine	60mg	30 + 6 Pills	106.65€ 101.57€
Priligy Generic Dapoxetine	60mg	120 + 10 Pills	341.26€ 325.01€

In the US, dapoxetine has been in phase III development. In May 2012, US-based Furiex Pharmaceuticals reached an agreement with ALZA Corp and Janssen Pharmaceuticals to market dapoxetine in the United States, Japan, and Canada, while selling the rights to market the drug in Europe, most of Asia, Africa, Latin America, and the Middle East to Menarini.

Medication details

This medicine contains lactose (a type of sugar). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop. Some medicines and PRILIGY may interfere with each other. linezolid, an antibiotic used to treat infection tryptophan, used to help your mood and help you sleep St John's wort (Hypericum perforatum), a herbal preparation.

When to take PRILIGY

PRILIGY should not be taken with the above listed medicines/ herbal preparations or within 14 days of stopping these medicines. Once you stop taking PRILIGY you will need to wait 7 days before taking these medicines/ herbal preparations. Other medicines or food and PRILIGY may interfere with each other. medicines for mental health problems other than depression medicines to thin your blood, such as warfarin certain medicines for fungal infections, including ketoconazole, itraconazole and fluconazole certain medicines for HIV, including ritonavir, saquinavir and atazanavir certain medicines used to treat high blood pressure and chest pain (angina), enlarged prostate, or erectile dysfunction (impotence), as these medicines may lower your blood pressure, possibly upon standing anti-inflammatory medicines such as ibuprofen or aspirin certain antibiotics for treating infection, such as erythromycin, telithromycin and clarithromycin Do not drink grapefruit juice within 24 hours prior to taking PRILIGY narcotics (strong pain medicines) or benzodiazepines such as valium. Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect PRILIGY. Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE.

Priligy is not a cure but manages symptoms.
Potential interactions include other serotonergic drugs.
Do not use if you have severe heart conditions.
Use caution if you have a history of mental health issues.
Store Priligy in a cool, dry place out of children’s reach.
Patients with liver problems should consult their doctor.
It may cause dizziness, so avoid operating machinery.
Dapoxetine is rapidly absorbed and metabolized.
The safety profile of Priligy has been extensively studied.

[10] Different dosages have different impacts on different types of PE.

Dapoxetine 90mg

Do not give your medicine to anyone else, even if they have the same condition as you. Be careful before you drive or use any machines or tools until you know how PRILIGY affects you. This medicine may cause dizziness, light-headedness, tiredness, drowsiness, fainting, having difficulty concentrating and blurred vision in some people. If you have any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous. Avoid alcohol while you are taking this medicine.

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The effects of alcohol, such as dizziness, drowsiness, slow reflexes or impaired judgement, may be increased if taken with PRILIGY. Follow the instructions on the carton on how to take care of your medicine properly. Keep your tablets in the pack until it is time to take them. If you take the tablets out of the pack they may not keep well. Store it in a cool dry place below 25°C and away from moisture, heat or sunlight; for example, do not store it: in the bathroom or near a sink, or in the car or on window sills. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but no difference is seen in men with acquired PE.

Priligy brand

You have not had water to drink in the past 4 to 6 hours You have been sweating for a long time You have an illness where you have a high temperature, diarrhoea or being sick If you feel like you might faint (such as feeling sick, feeling dizzy, light-headed, feeling weak, confused, sweaty or an abnormal heart beat), or feel light-headed when you stand up, immediately lie down so your head is lower than the rest of your body or sit down with your head between your knees until you feel better. This will stop you from falling and hurting yourself if you do faint. Do not stand up quickly after you have been sitting or lying down for a long time. Do not drive or use any tools or machines if you feel faint when taking this medicine. Tell your doctor if you faint when taking this medicine.

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Remind any doctor, dentist or pharmacist you visit that you are taking PRILIGY. Keep all of your doctor's appointments so that your progress can be checked. Talk to your doctor before you stop taking this medicine. You may have problems sleeping and feel dizzy after you stop taking it, even if you have not taken it every day. Do not take PRILIGY to treat any other complaints unless your doctor tells you to. [11] Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress and interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition.

Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)

Heat order priligy 60mg and dampness can destroy some medicines. Keep it where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. If you no longer need to take this medicine or it is out of date, take it to any pharmacy for safe disposal. Do not use this medicine after the expiry date.

Things you should not do

If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention. See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions about side effects. Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell. Other side effects not listed here may occur in some people. With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE.

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These medicines may be affected by PRILIGY or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines. Other medicines not listed here may be affected by PRILIGY or may affect how well it works. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. The recommended dose is one tablet (30mg), taken when you need it, about 1 to 3 hours before sexual activity.

Mechanism of action

Do not take more than one tablet once every 24 hours due to increased risk of side effects and lack of additional benefit. Swallow the tablet whole to avoid a bitter taste, with at least one full glass of water. PRILIGY may be taken with or without food. Do not drink grapefruit juice within 24 hours prior to taking PRILIGY. Grapefruit juice can increase the level of this medicine in your body. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when dapoxetine is used.

Clinical trials have shown Priligy effective for PE.
It’s designed specifically for men experiencing early ejaculation.
The onset of action is typically within an hour.
There are generic versions of dapoxetine available.
The cost of Priligy varies by country and pharmacy.
It does not affect sexual desire or performance directly.
Use caution with grapefruit juice, which may interfere.
Pre-existing health issues should be reviewed before use.
Ongoing research continues into PE treatments like Priligy.

[11] However, these SSRIs may need to be taken daily to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido.

Managing Expectations with Priligy Therapy