Archived from the original on 4 March 2016. ^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. ^ "Hidden Risks of Erectile Dysfunction 'Treatments' Sold Online".
- Sildenafil can sometimes cause flushing and nasal congestion.
- It is not a cure for erectile dysfunction, only a treatment option.
- Psychological factors can also affect erectile performance alongside medication.
- Sildenafil may sometimes interact with foods that contain high fat content.
- Regular exercise and stress management can complement treatment with sildenafil.
- The medication should be stored safely out of children's reach.
- Reporting side effects to a healthcare provider is important for safety.
- Sildenafil is typically started at a low dose, gradually increased if needed.
- It is important to follow the prescribed timing for medication intake.
- Discontinuing sildenafil should be discussed with a healthcare professional.
Archived from the original on 23 April 2019. ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal buy sildenafil online uk Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011. "Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules".
Warnings & Precautions
"Bears' Brandon Marshall says some NFL players use Viagra .. on the Field". Archived from the original on 5 March 2016. "Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist". ^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived from the original on 14 January 2012. "Onset and duration of action of sildenafil for the treatment of erectile dysfunction". ^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond". Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra! ^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction". "Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs". Archived from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef". Archived from the original on 1 November 2012.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Kamagra Oral Jelly | 100mg | 220 + 18 Sachets | 662.24€ 630.70€ | |
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Kamagra | 100mg | 60 + 4 Pills | 201.34€ 191.75€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Kamagra Oral Jelly | 100mg | 21 Sachets | 95.92€ 91.35€ |
^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture".
Mechanism of action
^ "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses". Archived from the original on 12 sildenafil 25mg tablets July 2018. "Young men add Viagra to their drug arsenal". Archived from the original on 4 September 2014. "Recreational use and misuse of phosphodiesterase 5 inhibitors".
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
Archived from the original on 21 August 2016. "Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006). "The rise of Viagra among British illicit drug users: 5-year survey data". "Does marijuana use play a role in the recreational use of sildenafil?". "A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009.
Dosage And Administration
"Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review". Archived from the original on 29 August 2021. "Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options". "Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis". "Interventions for preventing high altitude illness: Part 1.
FDA Approval Information
Archived from the original on 10 June 2017. ^ "FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems" (Press release). Archived from the original on 22 October 2016. "Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date". ^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra".
Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
"Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension". "Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions". Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association". Journal of the American College of Cardiology. Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019.
- Sildenafil helps improve erections by relaxing penile muscles.
- The drug's popularity increased rapidly after approval in the late 1990s.
- It is part of a class of medications called PDE5 inhibitors.
- Sildenafil's development marked a breakthrough for men's health.
- There are ongoing studies to expand sildenafil's therapeutic uses.
- Regular medical check-ups are advised for long-term sildenafil use.
- Generic sildenafil has made treatment more affordable worldwide.
- It’s crucial to adhere to prescribed doses to avoid adverse effects.
- The medication is often taken about 30 minutes before sexual activity.
- Using sildenafil responsibly can improve quality of life for many men.
Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021.
| Age Range | Suitability | Notes |
|---|---|---|
| 18-50 years | Usually suitable | Under doctor supervision |
| 51-70 years | Caution advised | Dose adjustment may be needed |
| Over 70 years | Use with caution | Potential drug interactions |
Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. ^ "Viagra to go generic in 2017 according to Pfizer agreement". Archived from the original on 1 sildenafil premature ejaculation December 2017. "Sex, Drugs and That Little Blue Pill". Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide". Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says".
Side Effects
During that year Viagra sales slumped to 38% that of Palpal. There were 2,958,199 prescriptions for Sildenafil in 2016 in England, compared with 1,042,431 in 2006. In 2018, Viagra Connect, a particular formulation of Sildenafil marketed by Pfizer, became available for sale without a prescription in the UK. Archived from the original on 12 October 2020. ^ "Viagra 25mg film-coated tablets Summary of Product Characteristics (SmPC)".
Cessation and Adverse Effects of Treatment
^ "Viagra Connect 50 mg film-coated tablets Summary of Product Characteristics (SmPC)". Archived from the original on 13 August 2020. Archived from the original on 11 October 2020. Archived from the original on 11 November 2020. ^ Nichols DJ, Muirhead GJ, Harness JA (6 March 2002).
Patient resources
"Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". The American Society of Health-System Pharmacists. Archived from the original on 23 April 2020. PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon]. "Sublingual sildenafil in the treatment of erectile dysfunction: faster onset of action with less dose". ^ "Global illicit medicines targeted by INTERPOL operation".
Viagra Versus Other ED Medications
"The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction". ^ "Drug Approval Package: Viagra (sildenafil citrate) NDA #020895". U.S. Food and Drug Administration (FDA). Archived from the original on 31 March 2021.
Sildenafil Tablets or Oral Suspension for PAH
Archived from the original on 12 August 2025. ^ "Sildenafil Drug Usage Statistics, United States, 2014 - 2023". "Generic Viagra: Two versions of sildenafil hit the market today". Archived from the original on 25 November 2018. Archived from the original on 12 February 2022.
Does sildenafil interact with other medicines (drug interactions)?
"With Viagra Now Available Over-The-Counter In The U.K., Will The U.S. "Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus". "Strategies for managing sexual dysfunction induced by antidepressant medication". The Cochrane Database of Systematic Reviews (5) CD003382. Archived from the original on 10 October 2020. Archived from the original on 10 December 2023.
- Sildenafil may improve confidence and sexual satisfaction in men with ED.
- The medication is also being researched for pulmonary hypertension treatment.
- Common side effects include dizziness, upset stomach, and vision changes.
- Rare side effects can include priapism, a painful prolonged erection.
- Alcohol can interfere with sildenafil's effectiveness and increase side effects.
- Patients should disclose any heart conditions before using sildenafil.
- Sildenafil may interact with other medications such as alpha-blockers.
- It is not suitable for individuals with severe liver or kidney problems.
- Taking large doses does not necessarily improve efficacy and increases risk.
- Always follow the prescribed dosage and discontinue if adverse effects occur.
^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 October 2013. "Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024. "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016.
Conclusion: Is Sildenafil Right for You?
Archived from the original on 26 January 2013. "Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America. "Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 14 August 2020. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd.